Long-Term Effectiveness and Safety of Nabiximols a THC CBD Spray in Clinical Practice

Published by Anthony Taylor on

Eur Neurol. 2014 Jun 18;72(1-2):95-102. [Epub ahead of print]

Long-Term Effectiveness and Safety of Nabiximols (Tetrahydrocannabinol/Cannabidiol Oromucosal Spray) in Clinical Practice.

Abstract

Background: Nabiximols (Sativex®), in a cannabinoid-based oromucosal spray, is an add-on therapy option for patients with moderate to severe multiple sclerosis spasticity (MSS) resistant to other medications. The study objective was to provide long-term data on clinical outcomes, tolerability, quality of life and treatment satisfaction for MSS patients receiving nabiximols in routine care. Methods: This was the 12-month prolongation of the MOVE 2 study, an observational, prospective, multi-centre 3-month non-interventional study conducted in a routine care setting across Germany. Structured documentation forms, questionnaires and validated instruments were used for data collection. Results: In total, 52 patients were included in the effectiveness analysis after 12 months. The mean spasticity numerical rating scale (NRS, 0-10) score decreased significantly from 6.0 ± 1.8 points at MOVE 2 baseline to 4.8 ± 1.9 points after 1 month and remained on this level after 12 months (4.5 ± 2.0 points); in patients classified as ‘initial responders’ (≥20% NRS improvement after 1 month) similar results were found (baseline: 6.3 ± 1.4 points; after 1 month: 4.0 ± 1.0 points; after 12 months: 4.3 ± 1.9 points). The majority of patients (84%) did not report adverse events. Conclusion: Real-life data confirm the long-term effectiveness and tolerability of nabiximols for the treatment of resistant MSS in everyday clinical practice. © 2014 S. Karger AG, Basel.

PMID:
24943098
[PubMed – as supplied by publisher]
Categories: News

Anthony Taylor

Anthony Taylor is a long time activist in the marijuana reform movement. He was responsible for changes to the initiative process and has been a persistent voice in Salem for marijuana reform. His recent efforts led to the addition of PTSD to the list of qualifying conditions for the use of medical marijuana as well as sentencing reform including the creation of misdemeanor possession of marijuana and hashish, a long overdue change in Oregon statute.

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